The two human cases are linked to nine cases of Mycobacterium bovis infection in cats in Berkshire and Hampshire last year.
Both people were responding to treatment, PHE said.
It said the risk of cat-to-human transmission of M. bovis remained “very low”.
M. bovis is the bacterium that causes tuberculosis in cattle, known as bovine TB, and other species.
Transmission of M. bovis from infected animals to humans can occur by breathing in or ingesting bacteria shed by the animal or through contamination of unprotected cuts in the skin while handling infected animals or their carcasses.
The nine cases of M. bovis infection in cats in Berkshire and Hampshire were investigated by PHE and the Animal Health and Veterinary Laboratories Agency (AHVLA) during 2013.
The findings of the investigation are…
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